Protein Details: Gamma-aminobutyric acid receptor subunit beta-1
Protein ID
ICDB_Pro_0357
Protein Name
Gamma-aminobutyric acid receptor subunit beta-1
Gene Name
Gabrb1; Gabrb-1
Organism
Rattus norvegicus (Rat)
Length
474 amino acids
AlphaFoldDB
AF-P15431-F1-model_v4.pdb
Function
Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA); a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels; also named GABA(A) receptors (GABAAR); consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA; GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential; thereby reducing nerve transmission. Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits; which may be involved in the regulation of sleep and wakefulness (By similarity).
Sequence
Ligand Binding
Binding Site
BINDING 122; /ligand="histamine": "ligand shared between two neighboring beta subunits"; /note="in chain B"; BINDING 181..182; /ligand="histamine": "ligand shared between two neighboring beta subunits"; /note="in chain B"; BINDING 182; /ligand="4-aminobutanoate": "ligand shared with the neighboring alpha subunit"; /note="in chain A"; /ligand="4-aminobutanoate": "ligand shared with the neighboring alpha subunit"; /note="in chain A"; /ligand="histamine": "ligand shared between two neighboring beta subunits"; /note="in chain B"
Disease
Location
DOI ID
10.1002/j.1460-2075.1989.tb03557.x; 10.1016/0169-328x(90)90017-8; 10.7554/elife.39383
RefSeq
NP_037088.1